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Grupo de Trabajo Especializado en Métodos Alternativos.
Speciality Group of the Spanish Toxicology Society. Non profit-making organization.


After several years of informal contacts between members of the Spanish Toxicology Society, agreement on the convenience of the formal constitution of the group was eventually reached due to the excellent opportunity provided when Spanish participants attended the Working Group on Complementary Methods sponsored by the International Council for Laboratory Animal Science (ICLAS) and the Spanish Research Council (CSIC) in 1995.


The main objective of the group is to stimulate the cooperation and coordination of the scientific activities to contribute to the development of new experimental methods, in vivo and in vitro, so as to reduce the number of animals used, refine techniques in order to reduce animal suffering, or replace the use of animals altogether (the three "r"s).

Another aim is to stimulate the participation of Spanish research groups in method prevalidation and validation programmes and to promote the regulatory acceptance of alternative methods, particularly in vitro toxicity methods.


Note: reports of the followings meetings are available at the main page, section ‘Documentos’)


  • ICLAS/CSIC Working Group on Complementary Methods, Talavera de la Reina, 1995.
  • Sessions on Alternative Methods, 3 Latinamerican Congress of Toxicology- XI Spanish Toxicology Congress, Tenerife, 1995
  • Meeting of GTEMA, 3 Latinamerican Congress of Toxicology- XI Spanish Toxicology Congress, Tenerife, 1995
  • Workshop on The Use of In vitro model systems for the investigation of molecular mechanisms of toxicity, EUROTOX-96, Alicante, 1996.
  • Seminar "Advances in the Application of In Vitro Alternative Methods to the Evaluation of Pharmaceuticals, Cosmetics and Chemicals", SmithKline Beecham, Tres Cantos, 1997
  • International Complutense Seminar "The Use of Animals in Research: Ethical Implications", Madrid, 1997
  • Meeting of Representants of European Centres on Alternatives, ECVAM, Italy, July, 1997.
  • Round Table "Alternative Methods in Basic and Applied Research", and sessions on Alternatives, XII Spanish Toxicology Congress, Zaragoza, 1997
  • Meeting of GTEMA, XII Spanish Toxicology Congress, Zaragoza, 1997
  • Meeting "Development and Coordination with ECVAM of Spanish Groups Interested in Alternative Methods", Glaxo Wellcome, Madrid, 1997
  • Course on In Vitro Methods: in preparation




  • ECVAM*: European Centre for the Validation of Alternative Methods
  • OECD: Organization for the Economic Cooperation and Development
  • AET: Spanish Toxicology Society
  • ETAC: Group of Alternative Toxicological Methods in Cuba
  • ERGATT: European Research Group for Alternatives in Toxicity Testing
  • ESTIV: European Society of Toxicology in Vitro
  • EUROTOX: European Society of Toxicology
  • CICYT: Interministerial Commission of Science and Technology (E)
  • ICLAS/CICYT/CSIC Working Group on Complementary Methods
  • SECAL: Spanish Society for Scientific Laboratory Animals
  • SEEA: Spanish Society for Animal Research
  • SEMA: Spanish Society of Mutagenesis
  • ADDA: Spanish Society for the Defence of Animal Rights


* Due to the splendid collaboration with ECVAM, and particularly with Dr M Balls and Dr J Fentem, the members of GTEMA are very well informed about ECVAM activities.


  • Publication "ICLAS/CSIC Working Group on Complementary Methods", de la Peña E, Guadaño A, Barrueco C, Repetto G, Gonzalez Menció F, Garcia Partida P, Madrid, 1995 (English summary available in the Spanish page, in Documents)
  • Stimulation of coordinated projects and application for grants related to alternative methods
  • Dissemination of information about activities in the field of alternatives in the official journal of the Society: Revista de Toxicología
  • GTEMA Newsletter (in Spanish), 4 numbers/year from 1996, distributted to all the members of the Spanish Toxicology Society (>400)
  • E-mail network: GTEMA Electronic Distribution List in Spanish: e-mail messages, >20 numbers/year, from 1996, distributted to more than 100 members


For more information, suggestions or comments, please contact:


  • Dr Guillermo Repetto
    Coordinator of GTEMA
    National Institute of Toxicology
    P. O. Box 863
    41080 – Sevilla, Spain.
    Tel 34 (9)5 4371233 Fax 34 (9)5 4370262


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